What are the Benefits of Cognizin® Citicoline?


By Robert Schinetsky


Choline is a vitamin-like essential nutrient that plays a critical role in brain development, muscle movement, metabolism, liver function, and nervous system function. Though choline lies at the very core of our health and wellness, it wasn’t recognized as an essential component of our biology until 1998.

Choline is found in a number of foods common to the diet including eggs, beef, salmon, liver, and Brussels sprouts. Due to the importance choline plays in development of the brain and nervous system, it’s one of the many nutrients supplied in a mother’s breast milk.  

And to top it off, choline also supports DNA repair, detoxification, and the production of one of the most important neurotransmitters in the body–acetylcholine (the “learning” neurotransmitter).

Unfortunately, many people simply do not get adequate choline in their diet to maximize their acetylcholine production, and thus often do not experience the heightened cognitive and physical performance that can accompany this important neurotransmitter.

More troubling is the fact that when choline is in short supply, the brain resorts to breaking down phosphatidylcholine, which are phospholipids that form cell membranes. Eventually, this could result in the development of cognitive decline.

Fortunately, a number of choline-based supplements have been developed over the years to boost choline intakes. One of the premier forms of supplemental choline available on the market is Cognizin® Citicoline.

What is Cognizin® Citicoline?

Cognizin® is a proprietary form of citicoline that is clinically studied to support mental energy, focus, and attention.

Citicoline, also known as cytidine diphosphate-choline (CDP-Choline) or cytidine 5'-diphosphocholine, is a naturally occurring, choline-containing molecule in the body composed of cytosine, pyrophosphate, ribose, and, of course, choline.

The complex molecule also servers as an intermediate in the production of phosphatidylcholine (a phospholipid that serves as a structural component of cell membranes). One of the components of citicoline, cytidine, is a component of RNA and, when it gets into the brain, it is converted into Uridine.

Subsequently, uridine is used to synthesize more phosphatidylcholine.

So, in a sense, when using citicoline, you’re actually getting two powerful nootropic supplements in one. You get choline to support acetylcholine production and uridine (via cytidine) to fortify phosphatidylcholine production and cell membranes.

What are the Benefits of Cognizin®?

In reading about the importance of choline, you might wonder why not just supplement with pure choline, which you very well could do with a supplement such as choline bitartrate or choline citrate.

When supplementing with Cognizin® Citicoline vs. regular choline supplements, you get all of the benefits associated with choline supplementation (improve memory, greater learning, stronger muscle contractions, etc.), plus a number of other benefits.

Cognizin® vs. Choline Supplements

In addition to supplying the body with a highly bioavailable form of choline that supports acetylcholine production and the mind-muscle connection acetylcholine is required to signal muscle movement and contractions)[5], Cognizin® also:

  • Supports greater mental energy by increasing ATP stores in the frontal cortex[1]

    Note: This is important. While the brain accounts for only 2% of the body’s mass, it uses over 20% of the body’s energy at rest.

  • Increases dopamine and noradrenaline for greater focus and attention[2]

    *Note: This is particularly noteworthy as other choline supplements that only boost levels of acetylcholine and do not affect other neurotransmitter systems may lead to excess acetylcholine and can depress levels of dopamine and norepinephrine.

  • Enhances phospholipid production[3]

  • Exerts neuroprotective effects following traumatic brain injury[4]

  • Supplies the body with a source of pyrimidines which are used to produce phosphatidylcholine 

To top it off, neuroscientists are also exploring citicoline as a potential treatment option in patients with stroke, vascular dementia, Parkinson’s disease, and brain aging due to the versatile molecule’s ability to help stabilize cell membranes and reduce the presence of free radicals.[6] 

What is the Proper Dose of Cognizin®?

Clinical studies using Cognizin® observe benefit when supplementing with 250-500mg of Cognizin® per day.

Where Can I Find Cognizin® Citicoline?

C4 Energy Natural Zero supplies 250mg Cognizin® citicoline per serving along with natural caffeine from Coffeeberry® fruit extract and a collection of other powerful nootropic supplements in L-Tyrosine and Taurine.

C4 Energy Natural Zero contains no calories, no added sugar or artificial sweeteners. It provides a clean source of mental and physical energy to help you perform at your best morning, noon, and night. 

References

  1. Silveri, M. M., Dikan, J., Ross, A. J., Jensen, J. E., Kamiya, T., Kawada, Y., … Yurgelun-Todd, D. A. (2008). Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy. NMR in Biomedicine, 21(10), 1066–1075. https://doi.org/10.1002/nbm.1281
  2. McGlade, E., Agoston, A. M., DiMuzio, J., Kizaki, M., Nakazaki, E., Kamiya, T., & Yurgelun-Todd, D. (2019). The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males. Journal of Attention Disorders, 23(2), 121–134. https://doi.org/10.1177/1087054715593633
  3. Babb SM. Wald LL. Cohen BM. Villafuerte RA. Gruber SA. Yurgelun-Todd DA. Renshaw PF.: Chronic Citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study. Psychopharmacology. 161(3):248-54, 2002 May
  4. Baskaya MK. Dogan A. Rao AM. & Dempsey RJ.: Neuroprotective effects of citicoline on brain edema and blood-brain barrier breakdown after traumatic brain injury. Journal of Neurosurgery. 92(3):448-52, 2000
  5. Sanders L.M., Zeisel S.H. Choline – Dietary Requirements and Role in Brain Development Nutrition Today 2007; 42(4): 181–186.
  6. Blount PJ, Nguyen CD, McDeavitt JT. Clinical use of cholinomimetic agents: a review. J Head Trauma Rehabil. 2002;17:314–21.



The world’s most personalized pre-workout.
What is your stimulant tolerance?
zero
no stims for me thanks
low
a standard energy drink or cup of coffee is enough for me
medium
I drink multiple energy drinks or cups of coffee a day and/or I take pre-workout before the gym
high
I drink pre-workouts or energy drinks all day long
What is your goal?

Enhanced Performance
start a fitness program and/or take it to the next level

Weight Loss
fat loss and cutting

Muscle Growth
gain strength and size
Do you play collegiate or competitive sports?
yes
no
Alpha Amino BCAA

Alpha Amino is the ultimate performance, hydration and recovery sports drink powder. Its premium formula is built on the power of amino acids and formulated with ingredients that promote healthy fluid balance. Alpha Amino has 14 Amino Acids including a well-studied 2:1:1 BCAA ratio. These Amino Acids support the body’s ability to fuel skeletal muscles, preserve muscle glycogen stores and reduce protein breakdown.

  • Performance BCAA’s with 0g Sugar
  • 14 Amino Acids
  • 5g BCAA’s in the clinically studied 2:1:1 ratio
  • Electrolytes for hydration
  • Zero Stimulants & Zero Sugar
C4 Sport

C4 Sport! If you are a collegiate athlete or play sports competitively, C4 Sport is the perfect pre-workout for you because it is NSF Certified for Sport. C4 will help you tackle your training in the gym and on the field.

  • Boosts energy + focus
  • Enhances muscular endurance
  • 135mg of caffeine
  • Contains CarnoSyn® Beta Alanine, an amino acid, patented and clinically studied form of beta-alanine that has been shown to support muscular endurance
  • NSF certification is trusted by the MLB, NFL, NBA, NCAA, and everyday athletes alike
C4 Original

C4 Original! This is our best-selling pre-workout with more than 1.3 billion servings sold! C4 Original is perfect for you if you are new to the pre-workout game or you are seeking a lower stimulant C4.

  • Perfect for energy, focus and pumps
  • Good if you’re at the start your fitness journey/want to step up your workouts
  • 150mg of caffeine

Pro tip: If you are just starting out on a pre-workout, take half a scoop to assess tolerance level.*

Also available in convenient, bottled, ON THE GO formula!

C4 Ripped

C4 Ripped! If your goal is to lose weight, C4 Ripped is the perfect pre-workout for you.

  • Helps you train harder while supporting your body’s ability to burn fat
  • Creatine-free
  • Includes ingredients like Green Coffee Bean Extract to support weight loss
  • 150mg of caffeine
  • L-Carnitine Tartrate
C4 Extreme

C4 Extreme! If you love energy drinks and are always on the hunt for higher caffeine levels, C4 Extreme is for you.

  • 200mg Caffeine Explosive Energy®
  • 2g CarnoSyn® Beta- Alanine
  • 1g Nitramax (NO3-C)™
  • 1g Creatine Nitrate (NO3-T®)
C4 Ultimate

C4 Ultimate! If you’re a seasoned gym goer who loves pre-workouts and you’re looking for a fully-loaded, high-impact pre-workout, C4 Ultimate has what you need.

  • The most powerful C4 created
  • Per scoop: 300mg caffeine, 6g Citrulline Malate, 3.2g of CarnoSyn® Beta Alanine, 1.5g Nitrosigine®, 1.5g Creatine Nitrate, plus a powerful blend of nootropics
  • Fully-loaded formula packs a heavy punch of ingredients for focus, endurance, and pumps to help push you to your ultimate limit
  • Formulated for the ultimate – not entry level

Also available in convenient, bottled, ON THE GO formula!

BCAA Sport

BCAA Sport! If you are a collegiate athlete – or play sports competitively, BCAA Sport is a perfect stimulant-free option for you, because it is NSF® Certified for Sport®! BCAA Sport supports all day hydration & recovery, to maximize your workout results

  • All Day Hydration & Recovery
  • Supports All Day Hydration & Recovery
  • Zero Stimulants & Zero Sugar
  • 4G BCAA’s, 2.25G Added Amino Acids, 2G Added Glutamine, and Added Electrolytes
  • NSF® Certified for Sport®

CN3&trad; combines 3 forms of Creatine into a stimulant-free 3-in-1 Creatine complex! Providing 6.25 total grams consisting of micronized Creatine Monohydrate, Creatine Nitrate, and Creatine Hydrochloride. CN3&trad; is an amazing product to be taken before, during, or after a workout. Looking to amplify Strength & Pumps? CN3&trad; has got you covered!

  • Strength & Pump Amplifier
  • Stimulant free
  • Includes Creatine Monohydrate, Creatine Nitrate, and Creatine HCL
  • Unflavored or flavored
CLK

Cellucor CLK® is a stimulant free toning and sculpting supplement built on the power of four all-star weight loss ingredients: CLA, Raspberry Ketones, Carnitine, and the latest in diet support; Slimpro®.

  • Stimulant Free Fat Loss
  • Stimulant free toning and sculpting formula
  • Powered by four ingredients to support weight loss
  • Can be taken standalone, or paired with C4 Ripped (C4 Ripped contains stimulants)
  • Raspberry flavored softgels

Share & Contribute

Do you have a story or would you like to be a contributor? We'd love to hear from you.

Learn How